Protein Details: Neuronal acetylcholine receptor subunit beta-4

Protein ID

ICDB_Pro_1310

Protein Name

Neuronal acetylcholine receptor subunit beta-4

Gene Name

CHRNB4; ACRB4

Organism

Bos taurus (Bovine)

Length

496 amino acids

AlphaFoldDB

AF-Q8SPU6-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MRSALPLVLFSLVALCGRGDCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIQLQLSLAQLISVNEREQIMTTNIWLKQEWTDYRLAWNSSRYEGVNILRIPANRVWLPDIVLYNNADGSYEVSLYTNVVVRSNGSVMWLPPAICKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKMPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLNVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFIKRPRQQPSRAPQSSLARLTKSEATTTTTLAMGPTSSSNLYGNSMYFVNPGLAAPKSPVASDSAGIPRDFRLRSSGRFRQDVQEALEGVSFIAQHMKSDDLDQSVIEDWKYVAMVVDRLFLWVFVVVCVLGTVGLFLPPLFQTHTPSEEP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 82: "Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site"

Disease

Location

DOI ID

10.1046/j.1471-4159.1997.68020488.x

RefSeq

NP_776942.1